Abstract
Summary
Eighteen rabbits received intrathecal injections of 1.0 cc of talc suspension and were sacrificed 15 days later. Eight rabbits were untreated, serving as controls. These developed a meningeal reaction consisting of the appearance of histiocytes, macrophages, and giant cells. Ten animals treated with daily injections of 5 and 10 mg cortisone/kg showed a marked diminution of the meningeal response. Preliminary experiments with the use of hydrocortisone, injected intrathecally (10 mg) on the 1st and 7th days, also suggest diminution of the meningeal response to talc, though not as striking as with the use of intramuscular cortisone.
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