Abstract
Summary
Pepsin secretion and synthesis by mouse stomachs was studied in vitro. There is a basal rate of pepsin secretion, and carba-minoylcholine stimulates additional secretion. At the optimal drug concentration of 0.1 mg % the rate of secretion is 300% of the basal rate. Atropine inhibits the additional secretion caused by carbaminoylcholine but not the basal secretion. Histamine slightly stimulates pepsin secretion. The stomachs were supplied with amino acid mixtures, but no pepsin synthesis could be found. The implications of failure to find synthesis are discussed.
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