Abstract
Summary
Quantitative assays have been performed on extracts of synovial fluid aspirated from patients with rheumatoid arthritis, following intra-articular injection of cortisone, hydrocortisone, and their acetates. After one hour and 3 hours about 85% and 98% respectively had disappeared. There was no marked difference in rate of disappearance among the 4 compounds. Paper chromatographic analyses of post-injection extracts revealed well localized bands which were not seen in the control fluid from uninjected joints, indicating that metabolites were formed within the synovial cavity.
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