Abstract
Conclusions and summary
We have shown that a major factor responsible for the apparently nonlinear tissue clearances as measured in small animals is the return of isotope to the area of the injection in the arterial blood. By means of a relatively simple procedure it is possible to make correction for this error and to obtain reasonable, exponential clearances. This correction is made by subtracting the simultaneously measured activity over a corresponding area of tissue from the count over the injection site.
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