Abstract
Summary
A substance has been isolated from the adrenal venous blood of dogs which is approximately 25 times as potent as DOCA in producing sodium retention in adrenalec-tomized rats. It has not been established with certainty that this substance is pure. The material is slightly less polar than cortisone, exhibits an absorption maximum at 240 m/x, does not react with the phenylhydrazine reagent described by Porter and Silber, and does react with a phenylhydrazine reagent developed in this laboratory. The substance shows absorption maxima at 285 and 390 m/x when mixed with concentrated sulfuric acid.
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