Abstract
Summary
1. Sublethal hemorrhage in the normal fasted rat without a significant rise in plasma amino nitrogen is followed by a prompt suppression of fasting ketosis but is without effect on the increase in blood ketones consequent to a 30-minute intravenous infusion of sodium octanoate. 2. Hemorrhagic shock with rising plasma amino nitrogen levels is associated with a significant and progressive hypoketonemia and an inhibition of the rise in blood ketones ordinarily seen after sodium octanoate infusion. 3. Adrenalecto-mized rats exhibit the same decline in blood ketone levels during hemorrhage and shock as do normal rats. 4. The significance of these results with respect to effects of hemorrhage and shock on ketone production and utilization in the rat is discussed.
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