Abstract
Summary
The distribution of P32 following the injection of tagged TEPA∗ resulted in a fairly uniform distribution of P32 activity throughout the tissues of the body, but there was a greater concentration in the testes and a smaller concentration in bone as compared with injection of inorganic phosphate. There was a gradual accumulation of P32 in the spleen over a period of 30 hours following injection of TEPA∗, a result not observed with inorganic phosphate. Approximately 60% of the P32 activity in serum or plasma was associated with the globulin fraction, the remainder being in solution after precipitation of all proteins. About 20% of P32 was associated with nuclei and/or relatively heavy cellular components from liver, testes, and tumor tissue, most of the remaining activity being found in the protein-free filtrate. Some 65% of the activity was excreted over a period of 30 hours.
Get full access to this article
View all access options for this article.