Antagonism of Toxicity of Vanadium by Ethylenediamine Tetra Acetic Acid in Mice

Abstract

Summary

1. Calcium disodium ethylenediamine tetra acetate has been shown to prevent fatalities in mice injected with LD₇₀; LD_92.5, and LD₉₅ doses of vanadium as NaV0₃-H₂0; 80 to 90% of the mice injected at the LD₇₀ and LD_92.5 dose levels of vanadium surviving. 2. At least one millimole of EDTA must be present for every millimole of vanadium in order to show maximal prophylactic protection. 3. The time required for EDTA to detoxify an LD₇₀ dose of vanadium in mice appeared to be approximately two hours.