Electrophoretic Plasma Protein Patterns in Families with Hemophilia. ∗

Abstract

Summary

1. An electrophoretic anomaly, called α_x-globulin, has been found in the plasma of 14 hemophiliacs, i.e., in all of the active bleeders studied. 2. The same anomaly also has been observed in 8 members of hemophilic families who are not active bleeders (over 50% of this category), and who are not afflicted with any of the other diseases in which this anomaly has been found. 3. The electrophoretic anomaly is seen in female as well as in male subjects unlike the bleeding manifestation of hemophilia, found only in males. 4. There is a definite relationship between the prothrombin utilization and the appearance of the α_x-globulin anomaly in the plasma of members of hemophilic families.