Abstract
Summary
A study has been made on the effect of gonadophysin (Searle), an extract from sheep pituitaries which contains both follicle-stimulating and luteinizing hormone, on radiation-induced testicular atrophy in rats. Adult and immature male rats were given single exposures of 500 r total-body X-radiation and 800 r of X-radiation to the testes only in 3 fractionated doses, respectively. Gonadophysin was injected twice weekly for the first 4 to 6 weeks or from the 8th to 16th week following radiation exposures to evaluate the effectiveness of this agent on testicular atrophy and regeneration. Gonadophysin was found to increase slightly the degree of testicular atrophy and to inhibit testicular regeneration in rats.
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