Abstract
Summary
1. Hyper- and hypothyroid rats have been prepared and, along with euthyroid control rats, have been subjected to cannulation of the common bile duct and total daily bile collection for 7 days following cannulation, 2, Analysis of this bile for cholesterol and cholic acid revealed that the excretion of cholesterol is a reflection of the level of thyroid activity, and that cholic acid excretion is lowered in both hyper- and hypothyroidism. 3. After the third postoperative day, the ratio of cholic acid to cholesterol excreted in the bile was found to be relatively constant for each type of animal. 4. Cholic acid and cholesterol excretion in the bile was suppressed in both the hyper- and hypothyroid rats in the immediate postoperative period. In 3 or 4 days following cannulation, these levels reached a plateau.
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