Abstract
Summary
Treatment of commercial trypsin with suitable amounts of sodium hypochlorite greatly diminishes the hypotensive effect of the enzyme while its proteolytic activity is increased by approximately 50%. Similar changes result from treatment with hydrogen peroxide. Hypochlorite treated trypsin possesses a marked thromboplastic effect. Heparin prevents fatal embolism which otherwise results in a high percentage of cases following the intravenous injection of treated trypsin in rabbits. An increase in the readily activated protease fraction of plasma is observed after adding the treated enzyme to plasma in vitro and after injecting it intravenously.
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