Abstract
Summary
The hydrolysis of succinylmono-choline iodide in normal and heat inactivated human plasmas was compared to the hydrolysis of succinyldicholine dichloride. In normal plasma, the hydrolysis rate of succinylmonocholine iodide was found to be about 8 times slower than that of succinyldicholine dichloride. In heat inactivated plasma, the hydrolysis rate of succinylmonocholine iodide was negligible in the 2-hour observation period. Succinylmonocholine iodide in 1.0 to 2.5 mg/ kg doses inhibited neuromuscular transmission in the sciatic-gastrocnemius preparation of cats.
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