Abstract
Summary
1. A penicillium mold filtrate designated as 8450, and reported previously to have chemoprophylactic and chemotherapeutic activity against MM and Semliki Forest virus in mice, has been found to have demonstrable chemoprophylactic effects in 12 g mice infected peripherally with a special hamster passaged line of MEFl poliomyelitis virus. 2. Experiments are under way to find out (A) if stronger chemoprophylaxis can be obtained, (B) if more prolonged action can be obtained, and (C) if oral activity can be attained by 8450 against poliomyelitis virus.
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