Abstract
Summary
1. Due to a species sensitivity, whose nature is as yet unknown, PVP cannot be considered as a suitable colloid replacement fluid for the treatment of “shocked” dogs. 2. Intact dogs were variable in their response to small intravenous doses, 0.03 to 0.5 cc/kg of clinical PVP, but reacted severely to intravenous injections of 3 cc/kg exhibiting hypo-tension; hemoconcentration, and flushing of the skin of several hours'duration. 3. A small molecular weight fraction of PVP (K-21) produced severe reactions, while with a larger molecular weight fraction (K-62) only insignificant changes occurred. 4. Monomeric vinylpyrrolidone, in quantities far in excess of those found in clinical PVP solutions caused only transitory hypotension when injected undiluted. 5. Cortisone, used prophylatically over a period of 5 days prior to an injection of 3 cc/kg of PVP, decreased the severity and duration of the “canine reaction.” 6. Bled dogs did not tolerate well an infusion rate of 4 cc/kg/min; no fatalities resulted from infusions at half this rate.
Get full access to this article
View all access options for this article.