Unidentified Factors Capable of Reducing Stress in Iodinated Protein-Fed Rats. ∗

Abstract

Summary

A variety of natural products have been examined by means of a rat-survival assay for their ability to relieve the stress induced by iodinated casein administration. Mammalian muscle and alfalfa have been found to be excellent sources of the protective material(s) being measured, with liver and yeast also containing significant amounts. 2. Materials most active in the survival assay have been demonstrated to reduce thymus and seminal vesicle atrophy and kidney enlargement. When low levels of iodinated protein are employed, the adrenals are also partially restored to normal by the protective substances. Under the conditions employed, the spleens are significantly larger in the protected than the unprotected animals and the testes are not reduced in size by the thyroprotein administration.