Abstract
Conclusions
1. The PTC factor is concentrated in fractions III and IV-1 of the plasma proteins, Small quantities are found in fractions I and IV-4. None is found in fractions II and V. 2. Since fraction III contains thrombin and fraction IV-1 is poorly soluble, neither is suitable for intravenous administration. 3. The intravenous administration of fraction IV produced marked shortening of the whole blood coagulation time and reduction in residual serum prothrombin in PTC deficiency. The results appear superior to those which can be achieved by the intravenous administration of fraction I in hemophilia.
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