Abstract
Summary
1. Liver slices were incubated in a physiologic, buffered medium containing cortisone. Following incubation, the steroid fraction was recovered and the individual steroids isolated by paper chromatography. 2. Under the conditions of this experiment, 3 steroids were isolated on the paper chromatogram. The compound of greatest mobility and obtained in largest amount was cortisone, unaltered by incubation. The product of intermediate mobility was identified as Compound F. The least mobile compound was not identified. 3. On the basis of observations in the literature and the experimental data reported here, it is suggested that the metabolic activity of cortisone may actually be dependent on its conversion to Compound
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