Abstract
Summary
1. In the rabbit, intradermally injected crystalline egg albumin and bovine gamma globulin are taken up by histiocytic cells both locally and in the peripheral and medullary sinuses of the draining lymph node. Considerable quantities remain extracellular and presumably diffuse away to be dealt with elsewhere in the body. Polymorphonuclear cells, though present in considerable numbers, are not found to contain intact antigen. 2. In the draining node many lymphoid cells containing antigen are seen in the peripheral portions of the lymphoid nodules. 3. Egg albumin disappears much more quickly than bovine gamma globulin from the injected skin site and the draining node. 4. Passive sensitization and to a greater extent sensitization with Freund's adjuvants result in a slowing of both antigens' disappearance from skin and node. Adjuvant sensitized animals also show speeding up and intensification of phagocytosis of antigen in both localities.
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