Effects of d-Amphetamine on the Electroencephalogram of the Dog. ∗

Abstract

Summary

(1) In dogs prepared under thiopental and then immobilized with C₁₀, the injection of d-amphetamine causes a progressive increase in the frequency of the EEG, with a corresponding decrease in amplitude. These effects are maximal within the first hour. (2) When unanesthetized dogs are gently roused from sleep and then fully alerted, there is a rise in the frequency of the EEG, accompanied by a decrease in amplitude. (3) When d-amphetamine is injected into unanesthetized dogs, there is an increase in motor activity, the peak effect being reached within the first hour. There is some evidence for an increase in the frequency of the EEG. (4) These findings suggest that the effects of d-amphetamine on the EEG of the dog are parallel to its effect on behavior.