Incidence of Epidermal Methylcholanthrene Tumors in Mice After Administration of Cortisone. ∗ †

Abstract

Summary

1. Under the conditions of our experiments; the administration of cortisone to mice given external applications of methyl-cholanthrene in benzene or in carbowax 1500 was followed by some reduction of the early inflammatory response and by an increase in the incidence of epidermal tumor formation per number of animals, as compared with the results in the control experiments without cortisone injections. 2. Biopsy excisions performed in the methylcholanthrene-exposed skin areas appeared to increase still further the incidence of tumor formation in the mice treated with cortisone.