Abstract
Summary
1. The average portal venous pressure of rats was 15 cm H2O in the control period, 9 cm H2O after bleeding to an arterial pressure of 45 mm Hg, and 14.5 cm H2O immediatly after blood replacement. 2. Direct microscopy disclosed reduction in blood flow and narrowing of sinusoids, central venules and sublobular venules after bleeding from 0.7 to 1.0 cc/100 cm 2 of body surface. These changes became extreme after a hemorrhage of 2.1-2.4 cc/100 cm-2. Replacement transfusion after 3 hours of shock restored normal vessel caliber and blood flow, whether recovery followed or not.
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