Abstract
Summary
1. At plasma levels of 30 to 50 μg/cc, significant renal tubular secretion of pantothenic acid occurs. 2. It is probable that pantothenic acid is secreted by the same renal tubular transport mechanism involved in the transport of penicillin, phenolsulfonphthalein and PAH. 3. Probenecid can inhibit effectively the renal tubular secretion of pantothenic acid in man. 4. Probenecid enhances the plasma pantothenate levels obtained by the intravenous administration of sodium pantothenate in doses of 500 and 1000 mg.
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