Abstract
Summary
High cortisone dosage in ad-renalectomized dogs induces marked polyuria and polydipsia. The 24-hour urine volume may exceed control values by 5-10 fold. The daily renal excretion of Na, Cl, and K is increased, but considering the quantity of water eliminated, the urine is very dilute. Pituitrin is effective in controlling the polyuria and polydipsia only when administered in large amounts. The normal water balance was not re-established until long after cortisone injections were discontinued.
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