In vivo Inhibition of Blood Agglutinins by Polysaccharides from Animal Parasites. ∗

Abstract

Summary

1. Monkeys and rabbits were injected intravenously with various amounts of polysaccharides (dissolved in 0.85% saline) prepared from the muscle stage of Trichinella spiralis and from adult Ascaris lumbricoides from pig. 2. The titer of the α₂ isoagglutinins detected at 37 °C in the serums of the animals was reduced to negative for a period of 24 hours, and remained lower than the titer before inoculation for a period of 96 hours. 3. The titer of the α₁ was also reduced, but not as much as the α₂ agglutinins. 4. The titer of the agglutinins acting at 6°C against A₁, A₂ human, sheep, and the animal's own erythrocytes was also reduced after inoculation of the polysaccharide. 5. The possibility of injecting these polysaccharides to inhibit autoagglutination of erythrocytes as seen in certain pathological conditions is mentioned.