Abstract
Summary
The hemolytic action of 16 water-soluble ethers of glycerol has been examined and compared with their paralyzing and toxic action. Mephenesin was the most potent paralyzing agent and also possessed strongest hemolytic action. The 3-o-ethoxy-1,2-propanediol which approached mephenesin in paralyzing action, had only about one-half of its hemolytic activity. Several other water-soluble compounds which have considerably weaker hemolytic activity have been found. These compounds, however, were also much poorer paralyzing agents than mephenesin. No significant correlation between the solubility of the compounds, their water-oil partition ratios, and their paralyzing and hemolytic action was evident.
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