Eosinophile in Human Skin Homografting. ∗

Abstract

Summary and Conclusions

1. In full-thickness homografts in man, an increase of eosinophils occurred in the circulating blood stream and in tissues at the site of the graft. 2. Tissue eosinophilia is comparable in magnitude to the intensity of the circulatory eosinophilia. 3. Eosinophilia seems to be most intense when the epithelium of the homograft has sloughed and only the dermis remains intact. 4. Eosinophilia subsides and the count returns to normal levels as the last vestiges of the homograft's dermal pad sloughs away. 5. The number of eosinophils in a differential count increases at the expense of the polymorphonuclear cells, thus establishing an inverse relationship between the two types of cells in their responses to homografting.