Conjugation of N-Allylnormorphine by Liver Slices ∗

Abstract

Conclusions

1. N-Allylnormorphine can be estimated by the use of the Snell and Snell reagent, for a change in the alkyl group on the nitrogen does not change the intensity of the color produced. 2. N-Allylmrmorphine is oonjugated by surviving liver slim at the same rate as is morphine. In two and onehalf hours, about 75% of the two compounds is conjugated. 3. Because conjugation of the two compounds proceeds at essentially the same rate and the effective blocking dose of N-allylnormorphine is small, the latter compound must be more firmly fixed to the receptor site than is morphine.