Abstract
Summary
Of 192 mice with anterior chamber implants of newborn mouse lung. 97 were treated with systemic penicillin. An additional 193 mice were prepared with corneoscleral incisions into the anterior ocular chamber and 95 of this group received systemic penicillin. Beginning on the day of operation. penicillin was given in 5.000 unit doses over a 3-day period. The eyes were enucleated after an interval of 8 days. and studied microscopically. Seventy percent of mice receiving penicillin exhibited inflammation and/or infection in the transplanted eye, while 65% of the untreated mice with transplants had inflammatory and or an infectious response in the transplanted eye, the difference not being statistically significant. We may conclude that prophylactic penicillin at the therapeutic levels utilized is of no value in reducing the inflammatory response in the experimental anterior chamber technic of lung transplantation in the mouse eye.
The author wishes to acknowledge the valuable assistance of Drs. B. L. Sewton, Department of Pathology. and G. G. Robertson. Department of Anatomy. B.U.C.M.
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