Abstract
Summary
Synthetic polypeptides were investigated for their effects on rabbit blood coagulation in vitro and in vivo. The basic L-lysine polypeptides prolonged whole blood clotting time, increased prothrombin time and neutralized the effect of heparin. A synthetic L-glutamic acid polypeptide inhibited these effects of polylysine and protamine. In mice, guinea pigs and rabbits the lysine polypeptides-produced anaphylactoid symptoms which closely resembled those of protamine toxicity, A mechanism involving a combination of the basic polypeptides with acidic protein surfaces; or with heparin is discussed to explain some of these results.
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