Nutritional Factors in Hemodynamics: III. Importance of Vitamin C in Maintaining Renal VEM Mechanisms. ∗

Abstract

Conclusions and Summary

1. Compared with pair-fed vit. C supplemented controls, in vitro studies of renal tissue from guinea pigs on a vit. C free diet revealed a significant impairment of VEM forming capacity in 7 days. 2. Complete loss of in vitro renal VEM elaboration was found on the 14th day as well as on the 21st day of vit. C deficiency. 3. Impairment of renal VEM mechanisms was unrelated to loss of body weight. 4. The significance of these observations is discussed and related to other findings in hemorrhagic shock and vit. C deficiency in hemorrhagic shock.