Influence of Small Doses of Heparin on Fat Tolerance Curves in vivo and in vitro. ∗

Abstract

Summary

1. By the use of a well-standardized fat tolerance test, it has been possible to demonstrate the clearing effect of small doses of intravenously administered heparin in vivo. Furthermore by use of these small doses of heparin, we have demonstrated that individuals vary in their ability to clear their own sera in vitro after incubation. It has also been shown that an individual who clears well in vivo will probably clear well in vitro, as in the experiments described. Apparently the potent “clearing factor” formed, as for example in subject L, was very potent for the sera of other subjects who formed less “potent clearing” factor under similar conditions.