Abstract
Summary and Conclusions
1. The effect of cortisone administration on the metabolism of certain “B-vitamins” by the growing rat has been studied. This hormone did not influence the excretion of pyridoxine in the urine or the survival time of rats on a pyridoxinedeficient diet. Likewise, no effect was observed on the excretion of riboflavin or on the riboflavin content of the liver, although a marked increase in nitrogen excretion was recorded. Acid-treated cortisone exhibited no activity in counteracting the toxicity of aminopterin. 2. Eosinopenia was observed in rats receiving cortisone, but no differences in prothrombin times were found after 7 days of cortisone administration.
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