Inhibition of Thyroid function by cortisone and ACTH in Hypophysectomized Rats. ∗

Abstract

Summary

Administration of cortisone or ACTH decreases the TSH-induced uptake of I¹³¹ by the thyroid of hypophysectomized rats. This indicates that the suppression of the iodine concentrating function of the thyroid is brought about at extrapituitary levels, and not by suppression of TSH secretion from the pituitary. Some discrepancies of reported effects of adrenal hormones upon thyroid function are discussed.