Abstract
Summary
In newborn mice of strain A7 orchidectomy slight increased the incidence of leukemia. In such castrates, adrenal transplants doubled the incidence and conspicuously advanced the onset of the disease. Hypophyseal transplants made in conjunction with adrenal grafts increased the incidence of leukemia 4 times over that seen in non-grafted castrates. Prolonged hyperpituitarism associated with hyperadrenalism apparently exerted this leukemogenic effect.
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