Abstract
Summary
A study was made with the aid of continuous recording of the effects of an anesthetic dose of pentobarbital sodium and of supplemental doses of this drug required for the maintenance of surgical anesthesia upon arterial pressure, pulse rate and volume blood flow through the femoral artery of dogs. Following the administration of this anesthetic there was an immediate increase in volume blood flow and a fall in mean arterial pressure. Recovery to near pre-anesthetic control values usually occurred within 5 to 15 minutes. However, in some experiments recovery was not apparent for as long as 30 minutes after drug administration. Pulse rate remained increased throughout the duration of anesthesia.
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