Abstract
Summary and Conclusions
Experiments, using 110-120 g Sprague-Dawley male rats, were conducted to compare the activity of L-Thyroxine, sodium-L-Thyroxine and disodium-L-Thyroxine administered by subcutaneous and oral routes. There are no significant differences in the antipropylthiouracil effect of the three synthetic thyroxine compounds when administered by the same route. Considering that the gavage method permits some technical error, the amount of thyroxine necessary to inhibit the effect of propylthiouracil is approximately 50% more by the oral method than that necessary by subcutaneous injection.
Addendum. Since this paper went to press, a report of clinical work with sodium L-thyroxine has been published (Salter, William T., and Rosenblum, Ira, Am. J. Med. Sc., 1952, v224, 628). An assimilation by the patients of 67% of the orally given sodium L-thyroxine was reported.
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