Abstract
Summary and Conclusions
1. Young healthy female rats with normal estrous cycles when treated by simple bilateral ligation of the oviducts proximal to the uterus show prolonged periods of estrus. 2. When the distended capsule produced by this procedure is removed the animals resume normal estrous cycles. 3. The fluid obtained from the capsule contains estrogenic hormone as demonstrated by estrous smears in spayed females rats. 4 The noteworthy histological changes in the ovaries after 30 days of tubal ligation are marked follicle stimulation and the absence of new corpora lutea. After 90 days following ligation the ovaries become cystic, probably due to an inadequacy of the blood supply.
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