Abstract
Summary
1. The severity of the Arthus reaction in the rat was studied using known amounts of antigen and antibody. 2. Reverse Arthus reactions of minimal severity were obtained by intradermal sensitization with 5-10 μg anti-Ea or anti-SIII. 3. By intravenous sensitization direct Arthus reactions of medium severity were obtained with 800 μg and minimal reactions with 200 μg anti-SIII. 4. The threshold of the reaction in passive cutaneous anaphylactic experiments corresponded to 0.5-1.0 μg AbN for both the Ea-anti-Ea and SIII-anti-SIII systems. 5. The meaning of these findings is briefly discussed.
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