Abstract
Summary
A new host-virus system is described. The WS strain of Type A influenza virus was adapted to culture in the Ehrlich ascitic carcinoma of mice. This adapted strain of virus has been maintained through 38 serial passages in this tissue. The growth characteristics during a single passage have been described. Associated with the multiplication of this virus is a loss of viability of the host cell. The effect of this phenomenon on the course of development of an established ascitic tumor has been followed. The importance of this new host-virus system as a tool for the study of the mechanism of viral multiplication is discussed.
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