Abstract
Summary
1. The CF antibodies of pooled mumps antisera were stable for 2 months at −15 °C, and for 30 minutes at 60°C. 2. Sub-freezing temperatures had a markedly deleterious effect on the CF titer of mumps vaccine; temperatures above freezing had little effect; samples stored at 5°C for 3 years showed no drop in titer. After as many as 10 cycles of freezing and thawing, the CF titer of the vaccine remained unchanged. 3. Vaccine which had lost its CF antigen was able to stimulate the production of CF antibodies in guinea pigs provided Freund's adjuvant was used; however, the order of response was approximately 1/5 that produced by the same vaccine with the CF antigens intact. 4. The significance of these observations is discussed in relation to mumps vaccination studies.
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