Abstract
Conclusions
Unadapted type 1 (Brun-hilde) poliomyelitis virus inoculated intracerebrally in mice can be recovered 5 days and 10 days subsequently from the spinal cord of such mice as well as from their brains. Such virus does not appear to have undergone immunologic alteration and is neutralized by a type 1 (Brunhilde) monkey antiserum. The biological state of this unadapted virus in the central nervous system of the mice is such that it does not interfere with the propagation of mouse adapted type 2 (Lansing) poliomyelitis in such mice. It is suggested that the phenomenon may represent circumstances other than mere passive persistence of virus in the recipient mouse brain.
Get full access to this article
View all access options for this article.