Interference Between Japanese B Encephalitis Virus and Western Equine Encephalomyelitis Virus in the Rat

Abstract

Summary

If Japanese B encephalitis virus is instilled into the noses of 3- to 4-week-old rats 72 hours prior to the inoculation of Western equine encephalomyelitis virus by the same route a high percentage of the animals resist infection with the latter virus. If one inoculation of Japanese B virus preceded the Western equine virus 50% of the rats survived whereas 67% of the animals survived when 3 inoculations of Japanese B virus preceded the equine encephalomyelitis virus. Rats which survived when equine encephalomyelitis virus was instilled into their noses 72 hours following inoculation of Japanese B encephalitis virus by the same route were found to be susceptible to a second intranasal inoculation of equine encephalomyelitis virus.