Abstract
Summary
A small but highly significant sodium diuresis accompanied short-term thio-cyanate administration to uncomplicated hypertensive subjects on constant dietary regimens. Although slight but insignificant differences were observed between the mean responses of normotensives as compared to hypertensives, it was suggested that the similarity was attributable to the presence of a few hyperreactive and perhaps apre-hyper-tensive individuals in the normotensive series. The conversion of thiocyanate to cyanide in vivo was confirmed. Thiocyanate-induced sodium depletion was suggested as a possible factor in the depressor action of this agent, mediated either directly or through derived cyanide.
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