Abstract
Summary
1. The rates of lysis of guinea pig red cells by sodium choleate are altered by the adsorption and spontaneous detachment (“elution”) of purified PR-8 influenza virus hemagglutinin. During the adsorption phase, lysis is inhibited; after detachment of the agglutinin, there is a delayed increase in rate of lysis to values above normal. 2. Considered in conjunction with electrophoretic data for red cells treated with virus hemagglutinin, these results suggest that the hemagglutinin first attaches itself to a lytic “key-spot”. It then brings about, over a considerable neighboring area of the red cell surface, the changes which are manifested in alteration of the average electric charge density of the surface.
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