Abstract
Summary
Adrenalectomized mice varied in response to cortisone according to genetic constitution. Some strains were: a) highly sensitive, They responded significantly to 1 μg of cortisone, and maximally to 6 μg. b) Relatively insensitive. They responded to 3-6 pg but required 16 times the dose of a sensitive strain to approach maximum response. c) Too low in eosinophils to be practicable in calculations. Males were generally more reliable than females. Normal animals of 2 strains differed in response to mild stress. F1 hybrid males from C57BR/cd X C57BL/6 are recommended f,or the assay described.
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