Effects of Liver Fractions and Vitamin B 12 on Body and Organ Weights of Thyroid-Fed Rats

Abstract

Summary

Addition of thyroid to a caseinsucrose diet retards growth, causes hypertrophy of adrenal and spleen and atrophy of the thymus. Feeding 10% of defatted liver residue counteracts growth retardation and restores the adrenal and thymus weights to normal. It is without effect on the spleen. Liver concentrate N.F. has very little effect on growth or on the adrenal, but does tend to restore the thymus and spleen to normal. Vit. B¹² is without effect except in respect to the spleen where its prevents hypertrophy of this organ due to thyroid feeding. Lyxoflavin was found to have no antithyrotoxic effect on our diet.