Toxicity of Mono Methyl Ether of Dipropylene Glycol (Dowanol 50B) in Studies on Auricular Fibrillation

Abstract

Summary and conclusions

When administered intravenously to dogs anesthetized with pentobarbital, Dowanol 5OB in adequate dosage produces auricular fibrillation, but in 4 dogs was found unsuitable for use in repeated experiments on different days, since it caused respiratory depression, prolonged anesthesia, disturbances of gait, intestinal hemorrhages and death. One animal surviving a first experiment required a significantly higher single dose and higher cumulative dose for production of fibrillation during a second experiment and succumbed following the latter.