Abstract
Summary
1. Tyrothricin, or one or more of its components, reacts with streptokinase to prevent the activation of plasminogen and formation of plasmin. 2. Treatment of plasminogen with tyrothricin does not inhibit the activation of plasminogen by streptokinase. Plasminogen probably reacts with tyrothricin, preventing the inhibition of the added streptokinase by the antibiotic. 3. Tyrothricin does not inhibit the fibrinolytic activity of plasmin. 4. Penicillin, dihydrostreptomycin, polymyxin B, bacitracin, and sulfamerazine did not inhibit the activation of plasminogen by streptokinase nor the fibrinolytic activity of the plasmin.
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