Abstract
Summary
A study of the effect of hexo-barbital on the response of the guinea pig to injected potassium has revealed the following: 1) Potassium, even in maximally tolerated doses, is incapable of producing anesthesia when injected alone. 2) Potassium is capable of inducing a state indistinguishable from deep narcosis in pigs recovering from hexo-barbital anesthesia. 3) Potassium can produce moderately deep narcosis in guinea pigs given subanesthetic doses of hexobarbital. 4) Following the injection of small doses of hexobarbital, potassium can abolish the righting reflex in a fraction of the dose required when injected alone.
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